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Description

These studies highlighted several anti-cancer effects exerted by metformin on TC cells including: i) induction of cell death, ii) reduction of cell growth, iii) inhibition of the metastatic potential iv) modulation of chemokines in the tumor microenvironment, v) de-differentiating effects (increase in iodine up-take) (Klubo-Gwiezdzinska et al., 2013

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Studies show that growth factors and peptide drugs that can cross the bloodbrain barrier (BBB) better are more potent than those that do not cross the BBB